Anti-CD20 treatment of giant cell hepatitis with autoimmune hemolytic anemia.

@article{Paganelli2014AntiCD20TO,
  title={Anti-CD20 treatment of giant cell hepatitis with autoimmune hemolytic anemia.},
  author={Massimiliano Paganelli and Natacha Patey and Lee M. Bass and Fernando Alvarez},
  journal={Pediatrics},
  year={2014},
  volume={134 4},
  pages={
          e1206-10
        }
}
Giant cell hepatitis with autoimmune hemolytic anemia (GCH-AHA) is a rare autoimmune disease of infancy characterized by severe liver disease associated with Coombs-positive hemolytic anemia. We recently showed that GCH-AHA is probably caused by a humoral immune mechanism. Such data support the use of rituximab, an anti-CD-20 monoclonal antibody specifically targeting B lymphocytes, as a treatment for GCH-AHA. We describe here the detailed clinical evolution of 4 children with GCH-AHA who… CONTINUE READING

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Copyright © 2014 by the American Academy of Pediatrics

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