Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade.

@article{Chavin1994AntiCD2MS,
  title={Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade.},
  author={Kenneth D Chavin and L H Qin and R W Yon and Jianhua Lin and H. Yagita and Jonathan S. Bromberg},
  journal={Journal of immunology},
  year={1994},
  volume={152 8},
  pages={
          3729-39
        }
}
The mechanism by which anti-CD2 mAbs inhibit hapten-specific and alloantigen specific CTL was explored. In vivo administration of alpha-CD2 mAbs resulted in 80 to 100% inhibition of alloantigen specific CTLs. Mixing cells from control animals with cells from alpha-CD2-treated groups demonstrated transferable suppression of CTL (40-67% suppression). These suppressor cells were CD4+CD8- and associated with increased IL-4 and TGF-beta in culture as compared with controls. Anti-CD2 mAbs added at… CONTINUE READING
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