Anti-CD2 (T, p50) intact ricin immunotoxins for GVHD-prophylaxis in allogeneic bone marrow transplantation.

@article{Uckun1986AntiCD2P,
  title={Anti-CD2 (T, p50) intact ricin immunotoxins for GVHD-prophylaxis in allogeneic bone marrow transplantation.},
  author={F. Uckun and S. M. Azemove and D. E. Myers and D. Vallera},
  journal={Leukemia research},
  year={1986},
  volume={10 2},
  pages={
          145-53
        }
}
We evaluated the inhibitory effects of two immunotoxins (IT) synthesized by linking two different anti-CD2 (T, p50) murine monoclonal antibodies (MoAb) to intact ricin (R). Pretreatment with 1000 ng ml-1 35.1-R or OKT 11a-R inhibited PHA-induced T-cell proliferation by 93% and 86%, respectively. At this IT concentration generation of alloreactive cytotoxic T-cells (CTL) was inhibited by more than 99% by either IT. 35.1-R and OKT 11a were minimally toxic to natural killer (NK) effectors or… Expand
Human T Lymphocyte Differentiation Antigens as Target for Immunotoxins or Complement‐Mediated Cytotoxicity
Immunotoxins for ex vivo bone marrow purging in human bone marrow transplantation.
  • D. Vallera
  • Medicine
  • Cancer treatment and research
  • 1988
Immunotoxins containing ricin.
Immunotoxins for the therapy of graft versus host disease.
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