Anti-CCP antibodies: the past, the present and the future

@article{Venrooij2011AntiCCPAT,
  title={Anti-CCP antibodies: the past, the present and the future},
  author={W. J. Venrooij and J. V. Beers and G. Pruijn},
  journal={Nature Reviews Rheumatology},
  year={2011},
  volume={7},
  pages={391-398}
}
Rheumatoid arthritis (RA) is an autoimmune disease characterized by autoantibodies against citrullinated antigens. The importance of citrulline for the epitopes bound by these autoantibodies, referred to as ACPA (anti-citrullinated peptide/protein antibodies), was first described in 1998. In addition to citrullinated proteins, cyclic citrullinated peptides (CCP) can also be used as test substrates for detecting ACPA. The standard test for these antibodies is the second-generation CCP (CCP2… Expand
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270 Citations
Highly Influential Citations
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Background Citations
99
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Paper Mentions

Observational Clinical Trial
Clinical Follow-up of Anti-Carbamylated Antibody Status in Rheumatoid Arthritis
Patients with rheumatoid arthritis (RA) with positive antibodies against carbamylated proteins (anti-CarP) have a more severe clinical course. The primary objective of this study… Expand
ConditionsRheumatoId Arthritis
Universidad Autonoma de Nuevo Leon
June 2016 - December 2018

270 Citations

Citation Type

Citation Type

Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 ‘shared epitope’ alleles
  • 67
  • PDF
Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment.
  • 81
The influence of ACPA status and characteristics on the course of RA
  • 153
Anti-citrullinated peptide antibodies and rheumatoid factor isotypes in the diagnosis of rheumatoid arthritis: an assessment of combined tests.
  • 18
The role of anti-cyclic citrullinated peptide (CCP) antibodies in early detection of rheumatoid arthritis: an overview of the INOVA Diagnostics, Inc. QUANTA Lite CCP assays.
  • 3
Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins
  • 8
  • PDF
From Citrullination to Specific Immunity and Disease in Rheumatoid Arthritis
  • 3
Investigation of the role of neutrophils in the production of autoantigens in patients with rheumatoid arthritis
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Anti-Citrullinated Peptide/Protein Antibodies and Structural Prognosis of Rheumatoid Arthritis: Quantity Versus Quality
  • O. Meyer
  • Medicine
  • The Journal of Rheumatology
  • 2012
  • 2
  • PDF
AB0218 Rheumatoid Factor Is Associated with More Parameters of The Disease Activity than Anti-Citrullinated Peptide Antibodies in Patients with Rheumatoid Arthritis
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References

SHOWING 1-10 OF 109 REFERENCES
Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis.
  • 280
Anti-CCP antibodies, a highly specific marker for (early) rheumatoid arthritis
  • 108
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide.
  • 1,436
Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis
  • 94
  • PDF
Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles
  • 178
Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients.
  • 213
The value of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: do they imply new risk factors?
  • 23
Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis.
  • 84
The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis
  • 133
Anti-cyclic citrullinated peptide positivity in non-rheumatoid arthritis disease samples: citrulline-dependent or not?
  • 50
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