Anti-CCP antibodies: the past, the present and the future

  title={Anti-CCP antibodies: the past, the present and the future},
  author={W. J. Venrooij and J. V. Beers and G. Pruijn},
  journal={Nature Reviews Rheumatology},
  • W. J. Venrooij, J. V. Beers, G. Pruijn
  • Published 2011
  • Medicine
  • Nature Reviews Rheumatology
  • Rheumatoid arthritis (RA) is an autoimmune disease characterized by autoantibodies against citrullinated antigens. The importance of citrulline for the epitopes bound by these autoantibodies, referred to as ACPA (anti-citrullinated peptide/protein antibodies), was first described in 1998. In addition to citrullinated proteins, cyclic citrullinated peptides (CCP) can also be used as test substrates for detecting ACPA. The standard test for these antibodies is the second-generation CCP (CCP2… CONTINUE READING
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