Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity.

@article{Chai2010AntiAspergillusHH,
  title={Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity.},
  author={Louis Yi-Ann Chai and Frank L van de Veerdonk and Renoud J. Marijnissen and Shih-Chin Cheng and Ai Leng Khoo and Magda P. C. Hectors and Katrien Lagrou and Alieke G. Vonk and Johan Maertens and Leo A B Joosten and B. -J. Kullberg and Mihai G Netea},
  journal={Immunology},
  year={2010},
  volume={130 1},
  pages={46-54}
}
Both interferon-gamma-producing type 1 T helper (Th1)- and interleukin-17 (IL-17)-producing Th17 cells have been proposed to be involved in anti-fungal host defence. Although invasive aspergillosis is one of the most severe human fungal infections, little is known regarding the relative importance of the Th1 versus Th17 cellular immune pathways for the human anti-Aspergillus host defence. Using human peripheral blood mononuclear cells and a system consisting of monocyte-derived macrophages with… CONTINUE READING

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