Anti-Angiogenic and Anti-Inflammatory Effects of SERPINA3K on Corneal Injury

@inproceedings{Liu2011AntiAngiogenicAA,
  title={Anti-Angiogenic and Anti-Inflammatory Effects of SERPINA3K on Corneal Injury},
  author={Xiaochen Liu and Zhirong Lin and Tong Zhou and Ronrong Zong and Hui He and Zhen Liu and Jian-xing Ma and Zu-guo Liu and Yueping Zhou},
  booktitle={PloS one},
  year={2011}
}
SERPINA3K is a member of the serine proteinase inhibitor (SERPIN) family. Here we evaluated the therapeutic effects of SERPINA3K on neovascularization and inflammation in a rat cornea alkali burn model that is commonly employed to study corneal wounding. Topical treatment of the injured rat cornea with SERPINA3K (20 µg/eye/day) for 7 days significantly decreased the neovascular area, compared with the groups treated with BSA or PBS. The SERPINA3K treatment also ameliorated the corneal… CONTINUE READING

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