Anti-Angiogenesis Therapy in the Vx2 Rabbit Cancer Model with a Lipase-cleavable Sn 2 Taxane Phospholipid Prodrug using αvβ3-Targeted Theranostic Nanoparticles

@inproceedings{Pan2014AntiAngiogenesisTI,
  title={Anti-Angiogenesis Therapy in the Vx2 Rabbit Cancer Model with a Lipase-cleavable Sn 2 Taxane Phospholipid Prodrug using αvβ3-Targeted Theranostic Nanoparticles},
  author={Dipanjan Pan and Anne H. Schmieder and Kezheng Wang and Xiaoxia Yang and Angana Senpan and Grace Cui and Kendall Killgore and Benjamin Youngho Kim and John S. Allen and Huiying Zhang and Shelton D. Caruthers and Baozhong Shen and Samuel A. Wickline and Gregory M. Lanza},
  booktitle={Theranostics},
  year={2014}
}
In nanomedicine, the hydrophobic nature of paclitaxel has favored its incorporation into many nanoparticle formulations for anti-cancer chemotherapy. At lower doses taxanes are reported to elicit anti-angiogenic responses. In the present study, the facile synthesis, development and characterization of a new lipase-labile docetaxel prodrug is reported and shown to be an effective anti-angiogenic agent in vitro and in vivo. The Sn 2 phosphatidylcholine prodrug was stably incorporated into the… CONTINUE READING

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with perfluorocarbon nanoemulsions

  • GM Lanza, SD Caruthers, PM Winter, MS Hughes, AH Schmieder, G Hu
  • 2010

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