Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils

@inproceedings{Zhu2018AntiAllergicIA,
  title={Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils},
  author={Jing Chuan Zhu and Jie Dong and Lu Ji and Peiyong Jiang and Ting Fan Leung and Dehua Liu and Lai Guan Ng and Miranda Sin-Man Tsang and Delong Jiao and Chun-Kwok Wong},
  booktitle={Front. Immunol.},
  year={2018}
}
IL-1 family regulatory cytokine IL-37b can suppress innate immunity and inflammatory activity in inflammatory diseases. In this study, IL-37b showed remarkable in vitro suppression of inflammatory tumor necrosis factor-α, IL-1β, IL-6, CCL2, and CXCL8 production in the coculture of human primary eosinophils and human bronchial epithelial BEAS-2B cells with the stimulation of bacterial toll-like receptor-2 ligand peptidoglycan, while antagonizing the activation of intracellular nuclear factor-κB… CONTINUE READING
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