Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy.

@article{Zhou2012AntiAIDSA8,
  title={Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy.},
  author={Ting Zhou and Emika Ohkoshi and Qian Shi and Kenneth F. Bastow and Kuo Hsiung Lee},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2012},
  volume={22 9},
  pages={
          3219-22
        }
}
In this study, 19 dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-dihydropyranoxanthone (DCX) derivatives, previously discovered as novel anti-HIV agents, were evaluated for their potential to reverse multi-drug resistance (MDR) in a cancer cell line over-expressing P-glycoprotein (P-gp). Seven compounds fully reversed resistance to vincristine (VCR) at 4 μM, a 20-fold enhancement compared to the first generation chemosensitizer, verapamil (4 μM). The mechanism of action of DCPs and… Expand
Recent insight into the biological activities of synthetic xanthone derivatives.
  • Shagufta, I. Ahmad
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2016
TLDR
This review has compiled and discussed recent developments on the pharmacological profile of synthetic xanthone derivatives for different therapeutic targets and offers support in the development of new xanthones derivatives as therapeutic agents. Expand

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