Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos.

@article{Wu2003AntiAIDSA5,
  title={Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos.},
  author={Jiu-hong Wu and Xi-hong Wang and Yang-hua Yi and Kuo-Hsiung Lee},
  journal={Bioorganic & medicinal chemistry letters},
  year={2003},
  volume={13 10},
  pages={1813-5}
}
Sixteen flavonoids and their derivatives isolated from Desmos spp. were evaluated for inhibition of HIV replication in H9 lymphocyte cells. 2-Methoxy-3-methyl-4,6-dihydroxy-5-(3'-hydroxy)cinnamoylbenzaldehyde (12) and lawinal (6) demonstrated potent anti-HIV activity with EC(50) values of 0.022 and 2.30 microg/mL and therapeutic indexes of 489 and 45.2, respectively. Compound 12 appears to be an excellent lead for further anti-HIV drug development. 

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