Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.

Abstract

Matairesinol (1) and harman (5), identified from Symplocos setchuensis, were found to inhibit HIV replication in H9 lymphocyte cells. Anti-HIV evaluation of 28 derivatives of 5 revealed that compound 19 showed potent activity with EC(50) and therapeutic index values of 0.037 microM and 210, respectively.

Cite this paper

@article{Ishida2001AntiAIDSA4, title={Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.}, author={Junichiro Ishida and H. K. Wang and Masayoshi Oyama and Marianna Cosentino and Chang Qi Hu and K H Lee}, journal={Journal of natural products}, year={2001}, volume={64 7}, pages={958-60} }