Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

@inproceedings{Yahata2011AntiADS,
  title={Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease},
  author={Naoki Yahata and Masashi Asai and Shiho Kitaoka and Kazutoshi Takahashi and Isao Asaka and Hiroyuki Hioki and Takeshi Kaneko and Kei Maruyama and Takaomi C Saido and Tatsutoshi Nakahata and Takashi Asada and Shinya Yamanaka and Nobuhisa Iwata and Haruhisa Inoue},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Alzheimer's disease (AD) is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life. The AD brain is characterized by deposition of amyloid β peptide (Aβ), which is produced from amyloid precursor protein by β- and γ-secretase (presenilin complex)-mediated sequential cleavage. Induced pluripotent stem (iPS) cells potentially provide an opportunity to generate a human cell-based model of AD that would be crucial for drug… CONTINUE READING
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