Anti- or Profibrillatory Effects of Na+ Channel Blockade Depend on the Site of Application Relative to Gradients in Repolarization


Sodium channel blockers are associated with arrhythmic sudden death, although they are considered antiarrhythmic agents. The mechanism of these opposing effects is unknown. We used a model of induction of ventricular fibrillation (VF) based on selective perfusion of the vascular beds of isolated porcine hearts (n = 8). One bed was perfused with sotalol (220… (More)
DOI: 10.3389/fphys.2010.00010


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