Anti-(transforming growth factor β) antibodies with predefined specificity inhibit metastasis of highly tumorigenic human xenotransplants in nu/nu mice

Abstract

Monoclonal antibodies (mAb) were prepared against conjugated transforming growth factor β1 (TGFβ1) peptides: amino acid positions 48–60 and positions 86–101. Two antibodies, mAb 16-3G1 [anti-(48–60)] and mAb 5-2G6 [anti-(86–101)] cross-reacted with native TGFβ1,-β2 and-β3 (16-3G1) or only with native TGFβ1 (5-2G6). Both mAb were used to characterize TGF… (More)
DOI: 10.1007/BF01517218

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