Anti-β₂-glycoprotein I IgG antibodies from 1-year-old healthy children born to mothers with systemic autoimmune diseases preferentially target domain 4/5: might it be the reason for their 'innocent' profile?

Abstract

BACKGROUND Anti-β₂-glycoprotein-I (anti-β₂GPI) were demonstrated to be pathogenic in the antiphospholipid syndrome (APS). However, they can be detected in patients with no features of APS, especially those affected by systemic autoimmune diseases (SAD), and so in healthy children. It has been suggested that anti-β₂GPI against domain 1 (D1) associate with… (More)
DOI: 10.1136/ard.2010.137281

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@article{Andreoli2011AntiglycoproteinII, title={Anti-β₂-glycoprotein I IgG antibodies from 1-year-old healthy children born to mothers with systemic autoimmune diseases preferentially target domain 4/5: might it be the reason for their 'innocent' profile?}, author={L Andreoli and Cecilia Nalli and Mario Motta and Gary L Norman and Zakera Shums and Susan Encabo and Walter L. Binder and Monica Nuzzo and Micol Frassi and Andrea Lojacono and Tadej Av{\vc}in and P A Meroni and Angela Tincani}, journal={Annals of the rheumatic diseases}, year={2011}, volume={70 2}, pages={380-3} }