Anti‑apoptotic effects of glycosaminoglycans via inhibition of ERK/AP‑1 signaling in TNF‑α‑stimulated human dermal fibroblasts.

  title={Anti‑apoptotic effects of glycosaminoglycans via inhibition of ERK/AP‑1 signaling in TNF‑$\alpha$‑stimulated human dermal fibroblasts.},
  author={Jungtae Na and Dong-Ho Bak and Song I Im and Hyangtae Choi and Jung Hyun Hwang and Su Yeon Kong and Yeon a No and Yonghee Lee and Beom Joon Kim},
  journal={International journal of molecular medicine},
  volume={41 5},
It has been established that glycosaminoglycans (GAGs) serve an important role in protecting the skin against the effects of aging. A previous clinical trial by our group identified that a cream containing GAGs reduced wrinkles and increased skin elasticity, dermal density and skin tightening. However, the exact molecular mechanism underlying the anti‑aging effect of GAGs has not yet been fully elucidated. The present study assessed the influence of GAGs on cell viability, collagen synthesis… 

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