Anti‐tumor necrosis factor‐α antibody treatment reduces pulmonary inflammation and methacholine hyper‐responsiveness in a murine asthma model induced by house dust

@article{Kim2006AntitumorNF,
  title={Anti‐tumor necrosis factor‐$\alpha$ antibody treatment reduces pulmonary inflammation and methacholine hyper‐responsiveness in a murine asthma model induced by house dust},
  author={J. Kim and L. McKinley and S. Natarajan and G. Bolgos and J. Siddiqui and S. Copeland and D. Remick},
  journal={Clinical \& Experimental Allergy},
  year={2006},
  volume={36}
}
Background/Aims Recent studies documented that sensitization and exposure to cockroach allergens significantly increase children's asthma morbidity as well as severity, especially among inner city children. TNF‐α has been postulated to be a critical mediator directly contributing to the bronchopulmonary inflammation and airway hyper‐responsiveness in asthma. This study investigated whether an anti‐TNF‐α antibody would inhibit pulmonary inflammation and methacholine (Mch) hyper‐responsiveness in… Expand
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