Anti‐inflammatory effect of pelubiprofen, 2‐[4‐(oxocyclohexylidenemethyl)‐phenyl]propionic acid, mediated by dual suppression of COX activity and LPS‐induced inflammatory gene expression via NF‐κB inactivation

@article{Shin2011AntiinflammatoryEO,
  title={Anti‐inflammatory effect of pelubiprofen, 2‐[4‐(oxocyclohexylidenemethyl)‐phenyl]propionic acid, mediated by dual suppression of COX activity and LPS‐induced inflammatory gene expression via NF‐$\kappa$B inactivation},
  author={Ji-Sun Shin and Seung Ryel Baek and Se Il Sohn and Young-Wuk Cho and Kyung-Tae Lee},
  journal={Journal of Cellular Biochemistry},
  year={2011},
  volume={112}
}
Pelubiprofen is a non‐steroidal anti‐inflammatory drugs (NSAIDs) that is related both structurally and pharmacologically to ibuprofen. Anti‐inflammatory properties of ibuprofen are due to its ability to both decrease prostaglandin synthesis by inhibiting the activities of cyclooxygenases (COXs) and IκB kinase‐β (IKK‐β). However, the exact mechanisms that accounts for the anti‐inflammatory effects of pelubiprofen are not reported. In this study, we investigated the molecular mechanisms how… Expand
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