Anti‐i, a Frequent Cold Agglutinin in Infectious Mononucleosis

@article{Rosenfield1965AntiiAF,
  title={Anti‐i, a Frequent Cold Agglutinin in Infectious Mononucleosis},
  author={Richard E. Rosenfield and Paul J. Schmidt and Robert C. Calvo and Mary H. Mcginniss},
  journal={Vox Sanguinis},
  year={1965},
  volume={10}
}
Anti-I and anti-i display preferential cold agglutination of red cells from normal adults and cord bloods respectively. Weak agglutinability by anti-I of red cells from some adults has been described [12] and genetic control for these differences has been postulated [6, 111. Using both kinds of test sera, erythrocytes from normal adults are I-positive and i-weak (or i-negative) whereas red cells from cord blood and from adults with unusual Ii genotype are i-positive and I weak (or I-negative… 
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TLDR
‘Complete’ and ‘incomplete’ cold antibody activities could not be separated by a variety of physicochemical and serological methods, supporting the concept that a single antibody is responsible for both direct agglutination and complement fixation.
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The anti-H specificity of the incomplete cold antibodies in normal human sera was confirmed by their failure to sensitize "Bombay" erythrocytes, demonstrating that pathologic cold agglutinins are unrelated to the incompletecold antibodies present in most normal sera.
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TLDR
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TLDR
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