Anti‐i, a Frequent Cold Agglutinin in Infectious Mononucleosis

  title={Anti‐i, a Frequent Cold Agglutinin in Infectious Mononucleosis},
  author={Richard E. Rosenfield and Paul J. Schmidt and Robert C. Calvo and Mary H. Mcginniss},
  journal={Vox Sanguinis},
Anti-I and anti-i display preferential cold agglutination of red cells from normal adults and cord bloods respectively. Weak agglutinability by anti-I of red cells from some adults has been described [12] and genetic control for these differences has been postulated [6, 111. Using both kinds of test sera, erythrocytes from normal adults are I-positive and i-weak (or i-negative) whereas red cells from cord blood and from adults with unusual Ii genotype are i-positive and I weak (or I-negative… 

Cold Agglutinins of Anti‐i Specificity in Alcoholic Cirrhosis

The incidence of anti-i antibody was determined in a hyperglobulinemic group of patients readily available to us, namely, patients with alcoholic cirrhosis to determine the incidence of cold agglutinins.

Cold agglutinins in infectious mononucleosis and heterophil-antibody-negative mononucleosis-like syndromes.

Cold agglutinins with anti-i specificity were seen mainly in heterophil-positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases) and in patients with various monon nucleosis syndromes and in a large control group.

Reappraisal of the Role of Anti‐i in Haemolytic Anaemia in Infectious Mononucleosis

Serologic evaluation of three patients during moderate to severe haemolytic anaemia in infectious mononucleosis revealed high thermal amplitude anti‐i in only one patient, demonstrating that haemorysis in these patients does not seem related to the interaction of anti‐IgG and IgGAnti‐i antibodies.

Antibody Formation in Infectious Mononucleosis

A more extensive study of other 19s antibodies in infectious mane nucleosis with particular reference to their contribution to the false-positive serology which sometimes occurs in this condition.

Natural and pathologic human autoimmune responses to carbohydrate antigens on red blood cells

  • L. Silberstein
  • Biology, Medicine
    Springer Seminars in Immunopathology
  • 2004
The occurrence of normal and pathogenic serum autoantibodies suggests that under certain conditions, autoreactive B cell clones escape from tolerance mechanisms, and this may explain why autoimmune hemolytic syndromes, especially in children, are often associated with viral dysregulation of certain autore active B cell cloning.

Coexisting Anti‐I and Anti‐Fl/Gd Cold Agglutinins in Infections by Mycoplasma pneumoniae

The findings support the hypothesis that postinfectious CA are directed against the receptor of the infectious agent.

Fatal autoimmune hemolytic anemia due to immunoglobulin g autoantibody exacerbated by epstein-barr virus.

A rare case of AIHA associated with an IgG autoantibody and exacerbated by EBV infection, causing a fatal hemolytic anemia is reported.

An Incomplete Cold‐Reactive γG Antibody with i Specificity in Infectious Mononucleosis 1

Summary. A new cold reactive antibody directed against fetal (i) cells is described in 90% of patients with infectious mononucleosis. It appears to be the 7S counterpart of the previously described

From Cold-Agglutinin Disease to Systemic Lupus Erythematosus: Lessons in Human B-Cell Tolerance and Its Breakdown

The study of VH4.34 B cells provides a unique opportunity to understand the fine tuning of autoreactive B cells necessary to maximize their protective role in innate immune responses while avoiding autoimmunity.

Heterophile antigens and antibodies in medicine.

Forssman antibodies are the best known example of antibodies that act on antigens of unrelated species.



Interactions between 131I Trace‐Labelled Cold Agglutinin, Complement and Red Cells

  • M. Harboe
  • Biology
    British journal of haematology
  • 1964
‘Complete’ and ‘incomplete’ cold antibody activities could not be separated by a variety of physicochemical and serological methods, supporting the concept that a single antibody is responsible for both direct agglutination and complement fixation.

The unitary nature of "complete" and "incomplete" pathologic cold hemagglutinins.

The anti-H specificity of the incomplete cold antibodies in normal human sera was confirmed by their failure to sensitize "Bombay" erythrocytes, demonstrating that pathologic cold agglutinins are unrelated to the incompletecold antibodies present in most normal sera.

The I Antigen and Antibody

The red cells of an English blood donor, Mr. M., are of the phenotype i: the anti‐I which is present in his serum is presumably a “naturally occurring” antibody for he has never been a recipient. The

Anti-i : a New Cold Antibody

The I antigen has an almost universal distribution, but five examples of i cells were found in testing 22,000 donors, suggesting that the Ii phenotypes arose by the action of two allelomorphic genes I and i.

Further Studies of the I Antigen and Antibody

The blood of a Puerto Rican, of a West Indian Negress and of several members of a Baltimore Negro family is described. The red cells of these people are apparently of the phenotype i and their serum

Type-specific cold auto-antibodies as a cause of acquired hemolytic anemia and hemolytic transfusion reactions: biologic test with bovine red cells.

An unusual example of acquired hemolytic anemia in which cold auto-antibodies of extremely high titer were detected in the patient's serum is described.

Ageing of Hæmoglobin

The authors cannot decide between the two following hypotheses : (1) there are metabolic exchanges between the fractions, contrary to the theory of the metabolic inertness of hæmoglobin ; (2) there is ageing of part of the hâmoglobin, which during this process changes its electric charge and becomes concentrated in one of the fractions.

Mycoplasma (Pleuropneumonia-Like Organisms) and Blood Group I; Associations with Neoplastic Disease

Mycoplasma (Pleuropneumonia-Like Organisms) and Blood Group I; Associations with Neoplastic Disease