Anti‐angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives

  title={Anti‐angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives},
  author={S. Rath and J. Liebl and R. F{\"u}rst and A. Ullrich and J. L. Burkhart and U. Kazmaier and J. Herrmann and R. M{\"u}ller and M. G{\"u}nther and L. Schreiner and E. Wagner and A. Vollmar and S. Zahler},
  journal={British Journal of Pharmacology},
BACKGROUND AND PURPOSE The use of tubulin‐binding compounds, which act in part by inhibiting tumour angiogenesis, has become an integral strategy of tumour therapy. Recently, tubulysins were identified as a novel class of natural compounds of myxobacterial origin, which inhibit tubulin polymerization. As these compounds are structurally highly complex, the search for simplified precursors [e.g. pretubulysin (Prt)] and their derivatives is mandatory to overcome supply problems hampering clinical… Expand
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