Anti‐U Recognizing a Variant of the U‐Blood Group

@article{Mentor1989AntiURA,
  title={Anti‐U Recognizing a Variant of the U‐Blood Group},
  author={J. Mentor and H. S. Richards},
  journal={Vox Sanguinis},
  year={1989},
  volume={56}
}
4 Citations
MNS Blood Group System
Mutations in GYPB exon 5 drive the S–s–U+var phenotype in persons of African descent: implications for transfusion
TLDR
Variable reactivity of S–s–U+var RBCs with monoclonal anti‐He or by anti‐U has been demonstrated, however the underlying molecular bases for this phenotype remain to be established. Expand
Characterization of antibodies produced by S‐s‐individuals
TLDR
The majority of antibodies produced by S‐s‐U‐ individuals are anti‐U plus anti‐glycophorin B and are analogous to the broadly reactive antibody produced by En(a‐) individuals whose red cells lack glycophor in A or have altered glycoph orin A. Expand
Heterogeneity of Anti‐U
TLDR
This chapter discusses adsorption-elution tests in recognition of the U-negative phenotype, and explains very clearly why anti-U described by Mentor and Richards reacted with 80% of “U-negative” donor units; the reactive bloods were from S-, sU+ (variant) donors and had been misclassified as ‘Unegative’ in tests with anti- U that do not react directly with such cells. Expand

References

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