Anti‐TNF‐α restricts dengue virus‐induced neuropathy

@article{Jhan2018AntiTNFRD,
  title={Anti‐TNF‐$\alpha$ restricts dengue virus‐induced neuropathy},
  author={Ming-Kai Jhan and Wei-Chun HuangFu and Yi-Fan Chen and J. Kao and Tsung-Ting Tsai and Min-Ru Ho and T. Shen and Po-Chun Tseng and Yung-Ting Wang and Chiou-Feng Lin},
  journal={Journal of Leukocyte Biology},
  year={2018},
  volume={104},
  pages={961 - 968}
}
Proinflammatory TNF‐α facilitates dengue virus (DENV) infection in endovascular dysfunction and neurotoxicity. The introduction of TNF‐α blocking therapy with Abs is performed to test its therapeutic effect in this study. In DENV‐infected mice, TNF‐α production in the brain accompanied the progression of neurotoxicity and encephalitis. DENV infection caused the loss of hippocampal neurons with TNF‐α expression around damaged regions, and immunostaining showed the induction of apoptosis in… Expand
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