Anti‐IgE‐assisted desensitization to egg and cow's milk in patients refractory to conventional oral immunotherapy

@article{MartorellCalatayud2016AntiIgEassistedDT,
  title={Anti‐IgE‐assisted desensitization to egg and cow's milk in patients refractory to conventional oral immunotherapy},
  author={Cristina Martorell-Calatayud and A V Michavila-Gomez and Antonio Martorell-Aragon{\'e}s and Natalia Molini-Mench{\'o}n and J C Cerd{\'a}-Mir and R F{\'e}lix-Toledo and M. D. De las Marinas-{\'A}lvarez},
  journal={Pediatric Allergy and Immunology},
  year={2016},
  volume={27}
}
To the Editor: Oral immunotherapy (OIT) is a significant focus of treatment for egg and cow’s milk food allergy, inducing desensitization in the majority of individuals with these sensitivities (1, 2). A major drawback of OIT is the frequency of adverse effects, and although most are mild and self-limited, the use of parenteral epinephrine is not infrequent. As many as 20–30% of food-allergic patients are refractory to desensitization, particularly patients with higher initial food-specific IgE… Expand
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References

SHOWING 1-10 OF 11 REFERENCES
Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy.
TLDR
A pilot phase I study in 11 children with cow’s milk allergy by using omalizumab (anti-IgE mAb; Xolair; Genentech, South San Francisco, Calif) in combination with relatively rapid oral milk desensitization to examine the safety of this approach and to determine whether subjects could be dosed up to 2000 mg milk within 7 to 11 weeks of initiating the desensItization. Expand
A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients.
TLDR
Among children with high-risk peanut allergy, treatment with omalizumab may facilitate rapid oral desensitization and qualitatively improve the desensItization process. Expand
Safety and efficacy profile and immunological changes associated with oral immunotherapy for IgE-mediated cow's milk allergy in children: systematic review and meta-analysis.
TLDR
OIT can be considered safe and effective (in terms of acquiring desensitization) and reasonably safe (mild-to-moderate adverse events, little need for parenteral epinephrine) in patients with CMA. Expand
Safety and Efficacy Profile and Immunological Changes Associated With Oral Immunotherapy for IgE-mediated Cow's Milk Allergy in Children: Systematic Review and Meta-Analysis
TLDR
OIT can be considered safe and effective (in terms of acquiring desensitization) and reasonably safe (mild-to-moderate adverse events, little need for parenteral epinephrine) in patients with CMA. Expand
Oral and sublingual immunotherapy for egg allergy.
TLDR
Current evidence suggests that OIT can desensitize a large number of egg-allergic patients, although it remains unknown whether long-term tolerance develops, and there was inconsistent methodological rigour in the trials. Expand
Oral immunotherapy for the treatment of food allergy
TLDR
Previous publications showing evidence for the induction of tolerance are specifically reviewed and varying safety, tolerability and efficacy parameters from previous reports are also discussed. Expand
Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab
TLDR
These phase 1 data demonstrate that rush OIT to multiple foods with 16 weeks of treatment with omalizumab could allow for a fast desensitization in subjects with multiple food allergies. Expand
Possible recurrence of symptoms after discontinuation of omalizumab in anti‐IgE‐assisted desensitization to egg
Luis Moral; Nuria Marco; Teresa Toral; Jes us Garde; Mar ıa J. Fuentes; Belen Garc ıa-Avil es; Cristina Montahud; Javier Perona & Mar ıa J. Fornies Pediatric Allergy and Respiratory Unit, HospitalExpand
Oral desensitization as a useful treatment in 2‐year‐old children with cow's milk allergy
TLDR
Evidence shows oral desensitization to be a potential intervention option for cow's milk protein (CMPs) allergy and its application in clinical practice is limited. Expand
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