Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage.

@article{Kuo2008AnthraxTS,
  title={Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage.},
  author={Shu-ru Kuo and Mark C. Willingham and Sarah H. Bour and E. A. Wijaya Andreas and Seong Kyu Park and Carney B Jackson and Nicholas S Duesbery and Stephen H Leppla and Wei-Jen Tang and Arthur E Frankel},
  journal={Microbial pathogenesis},
  year={2008},
  volume={44 6},
  pages={
          467-72
        }
}
Bacillus anthracis infections are frequently associated with severe and often irreversible hypotensive shock despite appropriate antibiotics and aggressive hemodynamic and pulmonary support. Based on the observations that the anthrax secreted proteins-protective antigen (PA), lethal factor (LF), and edema factor (EF) also produce shock and mortality in animal models, we chose to characterize further the clinical chemistries and microscopic pathology of toxin treated rats. Groups of three male… CONTINUE READING

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