Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis.

@article{Muehlbauer2007AnthraxLT,
  title={Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis.},
  author={Stefan M. Muehlbauer and Teresa Hope Evering and Gloria Bonuccelli and Raynal C. Squires and Anthony W Ashton and Steven A. Porcelli and Michael Phillip Lisanti and J{\"u}rgen Brojatsch},
  journal={Cell cycle},
  year={2007},
  volume={6 6},
  pages={758-66}
}
Murine macrophages have been classified as either susceptible or nonsusceptible to killing by anthrax lethal toxin (LT) depending upon genetic background. While considered resistant to LT killing, we found that bone marrow-derived macrophages (BMMs) from DBA/2, AKR, and C57BL/6 mice were slowly killed by apoptosis following LT exposure. LT killing was not restricted to in vitro assays, as splenic macrophages were also depleted in LT-injected C57BL/6 mice. Human macrophages, also considered LT… CONTINUE READING

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Mitochondrial impairment mediates cytolysis in anthrax lethal toxin-treated murine macrophages

  • A Alileche, RC Squires, SM Muehlbauer, MP Lisanti, J. Brojatsch
  • Cell Cycle
  • 2006

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