Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival.

@article{Ribot2006AnthraxLT,
  title={Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival.},
  author={Wilson J. Ribot and Rekha Panchal and Katherine C. Brittingham and Gordon T Ruthel and Tara A. Kenny and Douglas A Lane and Bob Curry and Timothy A. Hoover and Arthur M. Friedlander and Sina Bavari},
  journal={Infection and immunity},
  year={2006},
  volume={74 9},
  pages={5029-34}
}
Alveolar macrophages (AM) are very important for pulmonary innate immune responses against invading inhaled pathogens because they directly kill the organisms and initiate a cascade of innate and adaptive immune responses. Although several factors contribute to inhalational anthrax, we hypothesized that unimpeded infection of Bacillus anthracis is directly linked to disabling the innate immune functions contributed by AM. Here, we investigated the effects of lethal toxin (LT), one of the binary… CONTINUE READING

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