Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support

@article{Suffredini2017AnthraxIG,
  title={Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support},
  author={Dante A. Suffredini and Xizhong Cui and Dharmvir S. Jaswal and Kenneth E. Remy and Yan Li and Junfeng Sun and Steven B. Solomon and Yvonne Fitz and Mahtab Moayeri and Stephen H Leppla and Peter Q. Eichacker},
  journal={Intensive Care Medicine Experimental},
  year={2017},
  volume={5}
}
BackgroundAlthough anthrax immune globulin (AIG) improved survival in antibiotic-treated Bacillus anthracis-challenged animal models, whether it adds to the benefit of conventional hemodynamic support for B. anthracis toxin-associated shock is unknown.MethodsWe therefore tested AIG in sedated, mechanically ventilated canines challenged with 24-h B. anthracis lethal and edema toxin infusions and supported for 96 h with a previously demonstrated protective regimen of titrated normal saline and… 
A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models
TLDR
A review of the controlled preclinical experience of anthrax anti-toxin antibody preparations in antibiotic-treated B. anthracis models or in titrated hemodynamic-supported toxin-challenged canines examines the strength and weaknesses of these preclinical experiences.

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