Anthrax Edema Toxin Modulates PKA- and CREB-Dependent Signaling in Two Phases

Abstract

BACKGROUND Anthrax edema toxin (EdTx) is an adenylate cyclase which operates in the perinuclear region of host cells. However, the action of EdTx is poorly understood, especially at molecular level. The ability of EdTx to modulate cAMP-dependent signaling was studied in Jurkat T cells and was compared with that of other cAMP-rising agents: Bordetella… (More)
DOI: 10.1371/journal.pone.0003564

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