Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II.

@article{Tosa1998AnthraquinonesFN,
  title={Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II.},
  author={H. Tosa and Munekazu Iinuma and F. Asai and T. Tanaka and H. Nozaki and S. Ikeda and K. Tsutsui and M. Yamada and S. Fujimori},
  journal={Biological & pharmaceutical bulletin},
  year={1998},
  volume={21 6},
  pages={
          641-2
        }
}
  • H. Tosa, Munekazu Iinuma, +6 authors S. Fujimori
  • Published 1998
  • Biology, Medicine
  • Biological & pharmaceutical bulletin
  • In a series of searches for DNA topoisomerase II inhibitors from naturally occurring compounds, a wood extract of Neonauclea calycina MERR. (Rubiaceae) showed a moderate effect in vitro. Purification of the extract resulted in the isolation of seven known anthraquinones. The structures were characterized as damnacanthal, rubiadin 1-methyl ether, nordamnacanthal, morindone, damnacanthol, lucidin 3-O-primeveroside and morindone 6-O-primeveroside by spectral analysis, respectively. Damnacanthal… CONTINUE READING
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