Anthraquinone G503 Induces Apoptosis in Gastric Cancer Cells through the Mitochondrial Pathway

@inproceedings{Huang2014AnthraquinoneGI,
  title={Anthraquinone G503 Induces Apoptosis in Gastric Cancer Cells through the Mitochondrial Pathway},
  author={Lijun Huang and Ting Zhang and Shuai Li and Junting Duan and Fang Ye and Hanxiang Li and Zhigang She and Guoquan Gao and Xia Yang and Javier S. Castresana},
  booktitle={PloS one},
  year={2014}
}
G503 is an anthraquinone compound isolated from the secondary metabolites of a mangrove endophytic fungus from the South China Sea. The present study elucidates the anti-tumor activity and the underlying mechanism of G503. Cell viability assay performed in nine cancer cell lines and two normal cell lines demonstrated that the gastric cancer cell line SGC7901 is the most G503-sensitive cancer cells. G503 induced SGC7901 cell death via apoptosis. G503 exposure activated caspases-3, -8 and -9… CONTINUE READING

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