Anthranilic acid metabolism in the isolated perfused rat liver: detection and determination of anthranilic acid and its related substances using high-performance liquid chromatography with electrochemical detection.

@article{Naito1984AnthranilicAM,
  title={Anthranilic acid metabolism in the isolated perfused rat liver: detection and determination of anthranilic acid and its related substances using high-performance liquid chromatography with electrochemical detection.},
  author={Japan Michiro Naito and Eisaku Sasaki and Yoshihiro Ohta and Rikio Shinohara and Isao Ishiguro},
  journal={Biochemical pharmacology},
  year={1984},
  volume={33 20},
  pages={
          3195-200
        }
}
In order to elucidate the anthranilic acid metabolism in animal tissue, the metabolism was studied in the isolated perfused liver of rats. A sensitive and rapid method was devised for determination of anthranilic acid and its related substances using high-performance liquid chromatography with electrochemical detection. 5-Hydroxyanthranilic acid and anthranilamide, which have not been detected in animal tissue, were found in the perfusate and in the bile secreted from the perfused liver… CONTINUE READING
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