Anthranilic acid derivatives: a new class of non-peptide CCK1 receptor antagonists.

@article{Varnavas2003AnthranilicAD,
  title={Anthranilic acid derivatives: a new class of non-peptide CCK1 receptor antagonists.},
  author={A. Varnavas and L. Lassiani and V. Valenta and F. Berti and L. Mennuni and F. Makovec},
  journal={Bioorganic \& medicinal chemistry},
  year={2003},
  volume={11 5},
  pages={
          741-51
        }
}
Having successfully obtained new CCK(1) ligands holding appropriate groups on the anthranilic acid dimer used as molecular scaffold we were interested in increasing their micromolar affinity for the CCK(1) receptors by modifying the spatial relationship of the main pharmacophoric groups. Since, we have proposed simplified analogues reducing the anthranilic acid dimer to a monomer. In this stage of our research program we have prepared and tested on CCK receptors a series of N-substituted… Expand
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A new series of anthranilic acid dimer derivatives, characterized by the presence of the tryptophan residue in the C-terminus of the dimer, is described, which exhibited an improved affinity for the CCK-A receptor in comparison to that of either, the N-unsubstituted derivative and asperlicin. Expand
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