Anthranilic acid based CCK1 receptor antagonists: preliminary investigation on their second "touch point".

  title={Anthranilic acid based CCK1 receptor antagonists: preliminary investigation on their second "touch point".},
  author={A. Varnavas and L. Lassiani and V. Valenta and L. Mennuni and F. Makovec and D. Hadjipavlou-Litina},
  journal={European journal of medicinal chemistry},
  volume={40 6},
In this phase of structure-affinity relationship study of VL-0395, a new anthranilic acid based CCK1 selective antagonist, we propose a series of unnatural aminoacidic derivatives. The result of this work is the identification of a new CCK ligand, which possesses an affinity (IC50 = 35 nm) one order of magnitude greater than the lead and, as a general rule, it points out how the hypothesized receptorial pocket which accommodates the Phe residue allows much more structural modification than that… Expand
8 Citations
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