Anthranilic Acid: A Potential Biomarker and Treatment Target for Schizophrenia.

@article{Oxenkrug2016AnthranilicAA,
  title={Anthranilic Acid: A Potential Biomarker and Treatment Target for Schizophrenia.},
  author={Gregory Oxenkrug and Marieke van der Hart and Julien Roeser and Paul Summergrad},
  journal={Annals of psychiatry and mental health},
  year={2016},
  volume={4 2}
}
Dysregulation of Trp-Kyn pathway is the most recent hypothesis of mechanisms of schizophrenia. In particular, over-production of kynurenic acid (KYNA), one of the three immediate downstream metabolites of kynurenine (Kyn) along tryptophan (Trp): Kyn pathway, has been considered as a new target for therapeutic intervention in schizophrenia. Up-regulation of KYNA formation was suggested to occur at the expense of down-regulated production of 3-hydroxyKyn (3-HK), the second immediate downstream… CONTINUE READING
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