Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans

  title={Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans},
  author={Cassandra Coburn and Erik L Allman and Parag Mahanti and Alexandre Benedetto and Filipe Cabreiro and Zachary Pincus and Filip Matthijssens and Caroline Araiz and Abraham Mandel and Manolis Vlachos and Sally-Anne Edwards and Grahame Fischer and Alexander Dyoe Davidson and Rosina E. Pryor and Ailsa Stevens and Frank J. Slack and Nektarios Tavernarakis and Bart P. Braeckman and Frank C Schroeder and Keith Nehrke and David Gems},
  booktitle={PLoS biology},
For cells the passage from life to death can involve a regulated, programmed transition. In contrast to cell death, the mechanisms of systemic collapse underlying organismal death remain poorly understood. Here we present evidence of a cascade of cell death involving the calpain-cathepsin necrosis pathway that can drive organismal death in Caenorhabditis elegans. We report that organismal death is accompanied by a burst of intense blue fluorescence, generated within intestinal cells by the… CONTINUE READING
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