Anthracycline-induced cardiac toxicity is not increased by dietary omega-3 fatty acids.

@article{Germain2003AnthracyclineinducedCT,
  title={Anthracycline-induced cardiac toxicity is not increased by dietary omega-3 fatty acids.},
  author={Emmanuel Germain and Paule Bonnet and Lucie Aubourg and M. C. Grangeponte and V{\'e}ronique Chaj{\`e}s and Philippe Bougnoux},
  journal={Pharmacological research},
  year={2003},
  volume={47 2},
  pages={
          111-7
        }
}
Exogenous n-3 polyunsaturated fatty acids (PUFA) and specially docosahexaenoic acid (DHA) have been previously reported to potentiate the efficacy of anticancer agents that generate an oxidative stress, such as anthracyclines, by enhancing the susceptibility of cell membranes to lipid peroxidation. Since lipid peroxidation has also been suggested to mediate anthracycline-induced heart failure, we designed a study aimed at investigating whether a DHA-enriched diet coupled with controlled… CONTINUE READING

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