Anthracycline-associated cardiac and renal damage in rabbits. Evidence for mediation by vasoactive substances.

@article{Bristow1981AnthracyclineassociatedCA,
  title={Anthracycline-associated cardiac and renal damage in rabbits. Evidence for mediation by vasoactive substances.},
  author={Michael R. Bristow and Wayne A. Minobe and Margaret E. Billingham and Jane B. Marmor and G. Allan Johnson and B. M. Ishimoto and W Scott Sageman and John R. Daniels},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1981},
  volume={45 2},
  pages={157-68}
}
We tested the hypothesis that anthracycline-induced cardiac and renal damage is mediated by vasoactive substances. A 1-minute exposure to 5 micrograms per ml. of doxorubicin (DXR, Adriamycin) produced cardiac histamine release in isolated rabbit hearts. Under conditions in which histamine uptake and metabolism were impaired, the administration of DXR, 2 mg… CONTINUE READING