Anthracycline antibiotic pharmacology and metabolism.

  title={Anthracycline antibiotic pharmacology and metabolism.},
  author={Nicholas R. Bachur},
  journal={Cancer treatment reports},
  volume={63 5},
The anthracycline antibiotics show evidence of numerous interactions with cellular components and participation in several metabolic pathways. Small structural changes in the antibiotic molecule can produce major changes in intracellular localization and interaction. To date, we find that all of the anthracycline antibiotics form free radical intermediates through the catalysis of microsomal and nuclear electron-transport machinery. NADPH cytochrome P-450 reductase catalyzes the free radical… CONTINUE READING


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