Corpus ID: 24933741

Anthracycline antibiotic 2-hydroxyaclacinomycins. II. Production of 2-hydroxyaclacinomycins A and B by a new recombinant strain and their antitumor activities.

@article{Yoshimoto1991AnthracyclineA2,
  title={Anthracycline antibiotic 2-hydroxyaclacinomycins. II. Production of 2-hydroxyaclacinomycins A and B by a new recombinant strain and their antitumor activities.},
  author={A. Yoshimoto and O. Johdo and T. Ishikura and T. Takeuchi},
  journal={The Japanese journal of antibiotics},
  year={1991},
  volume={44 3},
  pages={
          277-86
        }
}
Anthracycline antibiotics 2-hydroxyaclacinomycins A and B were isolated and purified from the culture broth of a recombinant strain which was produced by protoplast fusion of two aclacinomycin-blocked mutants. 2-Hydroxyaclacinomycin B is a new compound for which chemical structure and the biological activity in vitro were determined. 2-Hydroxyaclacinomycins had a stronger antitumor activity against murine leukemic L1210 cells in mice than the parent antibiotic aclacinomycins. 
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