Anthocyans-rich Aronia melanocarpa extract possesses ability to protect endothelial progenitor cells against angiotensin II induced dysfunction.

@article{Parzonko2015AnthocyansrichAM,
  title={Anthocyans-rich Aronia melanocarpa extract possesses ability to protect endothelial progenitor cells against angiotensin II induced dysfunction.},
  author={Andrzej Parzonko and Aleksandra Oświt and Agnieszka Bazylko and Marek Naruszewicz},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2015},
  volume={22 14},
  pages={
          1238-46
        }
}
ANTHOCYANIN-RICH PHENOLIC EXTRACTS OF BLACK CHOKEBERRY (ARONIA MELANOCARPA) ATTENUATE INFLAMMATION INDUCED BY LIPOPOLYSACCHARIDE IN RAW 264.7 CELLS
TLDR
The results showed that Ame pre-treatment significantly ameliorated oxidative stress and inflammatory biomarker activities, as evidenced by reductions in the production of ROS, MDA, and NO and an attenuation of the cell apoptosis levels and the mRNA expression of apoptosis factors such as caspase-3 and caspases-9.
Preliminary Study: Purple Sweet Potato Extract Seems to Be Superior to Increase the Migration of Impaired Endothelial Progenitor Cells Compared to l-Ascorbic Acid
TLDR
At the dose of 25 μg/mL, PSP extract seems to be superior to the l-ascorbic acid dose of 250 μg/L to improve EPCs migration, while both treatments with PSP extract and l-ASCorbic Acid can improve the proliferation and migration of impaired EPCS.
Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2‑Nrf2 signaling pathway.
TLDR
Puerarin protected Ang II‑induced EPC dysfunction via activation of the ERK1/2‑Nrf2 signaling pathway, and was identified that the impaired EPC functions were due to inhibition of the phosphorylation of extracellular signal‑regulated kinase 1 and 2 and the degradation of nuclear factor erythroid 2 like 2 (NRF2).
Effect of Sweet Purple Potato (Ipomoea batatas L.) Extract and Vitamin C on Endothelial Progenitor Cell Migration in Stable Coronary Disease Patient
TLDR
Low number and function of Endothelial Progenitor Cells (EPC) are reduced in coronary artery disease patient, but increasing dose of sweet purple potato extract and vitamin C increased EPC migration dose-dependently.
Purple sweet potato extract and vitamin C increase the proliferation of endothelial progenitor cells from stable coronary artery disease patients
TLDR
PSP extract and vitamin C increased EPC proliferation dose-dependently and furthermore, PSP extract was presumably a better EPC differentiation inducer than vitamin C, which induced E PC proliferation better than PSP extract.
Chrysobalanus icaco L. fruits inhibit NADPH oxidase complex and protect DNA against doxorubicin-induced damage in Wistar male rats
TLDR
Correlation analyses between endpoints examined indicated that the mechanism underlying chemopreventive actions of C. icaco fruit was attributed to inhibition of NADPH oxidase complex manifested as low levels of DNA damage in animals exposed to DXR.
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway
TLDR
Sesn2 facilitated the viability of EPCs After treatment with Ang-II, as well as provided a potential therapeutic target to alleviate the progression of atherosclerosis.
The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases
TLDR
Reports on the impact of black chokeberry fruits and extracts against several cardiovascular diseases, e.g., hyperlipidemia, hypercholesterolemia, hypertension, as well as the antioxidant and anti-inflammatory effect of these fruits in the abovementioned disorders are summarized.
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References

SHOWING 1-10 OF 31 REFERENCES
Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells
TLDR
A. Melanocarpa fruit extract exhibits anti-inflammatory effects in HAECs by inhibiting the expression of endothelial CAMs, activation of NF-κB and production of ROS.
Anthocyanin-Rich Aronox Extract from Aroniamelanocarpa E Protects against 7β-Hydroxycholesterol-Induced Apoptosis of Endothelial Cells
TLDR
The protective action of the extract against apoptosis in endothelial cells may contribute to the potential benefits drawn from consumption of plant polyphenols.
Extract from Aronia melanocarpa fruits potentiates the inhibition of platelet aggregation in the presence of endothelial cells
TLDR
It is concluded that the potentiating effect of AM extract on the endothelial cell-mediated inhibition of platelet aggregation clearly depends on the used concentrations of Aronia-derived active compounds.
Effects of polyphenol-rich extract from berries of Aronia melanocarpa on the markers of oxidative stress and blood platelet activation
TLDR
Comparative studies indicate that the tested plant extract was found to be more reactive in blood platelets than the solution of pure resveratrol.
Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome.
TLDR
Aronia extract may be of benefit to patients with MS seems to result from the influence of anthocyanins and possibly other flavonoids on blood pressure, serum level of ET-1, lipids, and oxidative status (GSH-Px, SOD, TBARS).
In vivo influence of extract from Aronia melanocarpa on the erythrocyte membranes in patients with hypercholesterolemia
Summary Background Hypercholesterolemia increases cholesterol concentration in erythrocyte membranes, which results in decrease of membrane fluidity and decreases the deformability of red blood
Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress
TLDR
The data indicate that Ang II increased the expression of gp91phox mRNA in a dose-dependent manner, which was attenuated by Ang II type 1 (AT1) receptor antagonist valsartan, leading to the impairment of proliferative activity.
Nrf2 Gene Transfer Induces Antioxidant Enzymes and Suppresses Smooth Muscle Cell Growth In Vitro and Reduces Oxidative Stress in Rabbit Aorta In Vivo
Background—Reactive oxygen species (ROS) play a major role in vascular inflammation and pathophysiology of many vascular diseases such as atherosclerosis and injury-induced neointima formation after
Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis.
TLDR
Polyphenol-rich extracts of A. melanocarpa extracts exerted significant concentration dependent anti-aggregatory effects in both studied groups, which indicated that these effects may be independent of it's ability to modulate superoxide production.
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