Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution.

@article{Xia2007AnthocyaninPC,
  title={Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution.},
  author={Min Xia and Wenhua Ling and Huilian Zhu and Qing Xu Wang and Jing Ma and Mengjun Hou and Zhihong Tang and Lan Li and Qinyuan Ye},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 3},
  pages={
          519-24
        }
}
OBJECTIVE Intracellular tumor necrosis factor receptor-associated factors (TRAFs) translocation to lipid rafts is a key element in CD40-induced signaling. The purpose of this study was to investigate the influence of anthocyanin on CD40-mediated proinflammatory events in human endothelial cells and the underlying possible molecular mechanism. METHODS AND RESULTS Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6… CONTINUE READING

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