Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation.

@article{Xia2009AnthocyaninAC,
  title={Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation.},
  author={Min Xia and Wenhua Ling and Hui-lian Zhu and Jing Ma and Qing Wang and Mengjun Hou and Zhihong Tang and Honghui Guo and Chi Liu and Qingyuan Ye},
  journal={Atherosclerosis},
  year={2009},
  volume={202 1},
  pages={41-7}
}
CD40-mediated inflammatory signaling is a potent activator of endothelial cells (ECs) and effective in triggering the pathogenesis of atherosclerosis, a chronic inflammatory disease. Anthocyanin is considered to exert potent cardiovascular-protective effect partially through its anti-inflammatory property, however, the precise mechanism is still unknown. Here we chose cultured human umbilical vein endothelial cells (HUVECs) to explore the influence of anthocyanin on CD40-mediated endothelial… CONTINUE READING
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