Anthocyanin-Rich Aronox Extract from Aroniamelanocarpa E Protects against 7β-Hydroxycholesterol-Induced Apoptosis of Endothelial Cells

@article{ZapolskaDownar2008AnthocyaninRichAE,
  title={Anthocyanin-Rich Aronox Extract from Aroniamelanocarpa E Protects against 7β-Hydroxycholesterol-Induced Apoptosis of Endothelial Cells},
  author={Danuta Zapolska-Downar and Grażyna Nowicka and Grażyna Sygitowicz and Mirosław Jarosz},
  journal={Annals of Nutrition and Metabolism},
  year={2008},
  volume={53},
  pages={283 - 294}
}
Aims: It has been previously reported that dietary polyphenolic compounds have a positive effect in cardiovascular diseases, although the underlying mechanisms remain unknown. In this study, the effects of Aronox, an anthocyanin-rich extract from Aronia melanocarpa E, on human umbilical vein endothelial cell (HUVEC) apoptosis was investigated. Methods: Apoptosis was measured in HUVEC pretreated with Aronox and than treated with 7β-hydroxycholesterol (20 μg/ml). For the evaluation of apoptosis… CONTINUE READING

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Apoptotic signaling cascades