Anthelmintic efficacy of Flemingia vestita (Fabaceae): alteration in the activities of some glycolytic enzymes in the cestode, Raillietina echinobothrida

@article{Das2004AnthelminticEO,
  title={Anthelmintic efficacy of Flemingia vestita (Fabaceae): alteration in the activities of some glycolytic enzymes in the cestode,
Raillietina echinobothrida},
  author={Bidyadhar Das and Veena Tandon and Nirmalendu Saha},
  journal={Parasitology Research},
  year={2004},
  volume={93},
  pages={253-261}
}
AbstractThe crude root-peel extract of Flemingia vestita, genistein and praziquantel were tested against some selected glycolytic enzymes—hexokinase (HK), phosphofructokinase (PFK), phosphoenolpyruvate carboxykinase (PEPCK), pyruvate kinase (PK), lactate dehydrogenase (LDH), malate dehydrogenase (MDH) and malic enzyme (ME)—of the fowl tape worm, Raillietina echinobothrida. Following exposure to the various treatments, the activities of HK, PFK, PEPCK and LDH increased by 33–39%, 41–125%, 44–49… 
Effects of phytochemicals of Flemingia vestita (Fabaceae) on glucose 6-phosphate dehydrogenase and enzymes of gluconeogenesis in a cestode (Raillietina echinobothrida).
Effect of Lysimachia ramosa Wall. Ex Duby and Its n-Butanol Fraction on Glycogen Content and Some Energy Related Enzymes in the Cestode, Raillietina echinobothrida
TLDR
The result indicates that the intrusion of the phytoconstituents in the function of enzymes of energy generating pathway of R. echinobothrida, perhaps dispossesses the parasite from energy production leading to paralysis.
Biological significance of phosphoenolpyruvate carboxykinase in a cestode parasite, Raillietina echinobothrida and effect of phytoestrogens on the enzyme from the parasite and its host, Gallus domesticus
TLDR
The potential of these findings to validate PEPCK as the anthelmintic drug target for parasitism management is stressed, as antagonist behaviours of recombinantPEPCKs derived from the parasite and its host are reported.
Purification and characterization of phosphoenolpyruvate carboxykinase from Raillietina echinobothrida, a cestode parasite of the domestic fowl
TLDR
It is hypothesized that PEPCK may be a potential target site for anthelmintic action after it was purified from the parasite and its avian host and tested on phytochemicals from plant sources, which resulted in alteration of its activity.
Effects of Acacia oxyphylla and Securinega virosa on functional characteristics of Raillietina echinobothrida (Phylum: Platyhelminthes; Class: Cestoidea), a poultry cestode parasite
TLDR
Role of phyto-products in the changed physiology of cestode and their possible chemotherapeutic targets are discussed and a lot of disparity was noted in the free amino acid pool as the levels of many amino acids were seen to increase or decrease in relation to the levels observed in control parasites.
Effect of Punica granatum fruit peel on glucose-6-phosphate dehydrogenase and malate dehydrogenase in amphistome Gastrothylax indicus
TLDR
Following in vitro treatment with ethanolic and aqueous extracts of Punica granatum fruit peel and commercial anthelmintic, albendazole G-6-PDH activity was decreased, whereas MDH was suppressed by 24–41 %, compared to the respective control, indicating that phytochemicals of plant may act as potential vermifuge or vermicide.
Differential kinetics at PK/PEPCK branch point in the cestode, Raillietina echinobothrida.
Genistein: is the multifarious botanical a natural anthelmintic too?
TLDR
The potential beneficial role of genistein as a natural alternative in management of helminth parasites needs to be further explored, particularly considering its in vivo efficacy and pharmacokinetics.
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