Anthelmintic efficacy of Flemingia vestita (Fabaceae): alteration in the activities of some glycolytic enzymes in the cestode, Raillietina echinobothrida

  title={Anthelmintic efficacy of Flemingia vestita (Fabaceae): alteration in the activities of some glycolytic enzymes in the cestode,
Raillietina echinobothrida},
  author={Bidyadhar Das and Veena Tandon and Nirmalendu Saha},
  journal={Parasitology Research},
AbstractThe crude root-peel extract of Flemingia vestita, genistein and praziquantel were tested against some selected glycolytic enzymes—hexokinase (HK), phosphofructokinase (PFK), phosphoenolpyruvate carboxykinase (PEPCK), pyruvate kinase (PK), lactate dehydrogenase (LDH), malate dehydrogenase (MDH) and malic enzyme (ME)—of the fowl tape worm, Raillietina echinobothrida. Following exposure to the various treatments, the activities of HK, PFK, PEPCK and LDH increased by 33–39%, 41–125%, 44–49… 
Effects of phytochemicals of Flemingia vestita (Fabaceae) on glucose 6-phosphate dehydrogenase and enzymes of gluconeogenesis in a cestode (Raillietina echinobothrida).
Effect of Lysimachia ramosa Wall. Ex Duby and Its n-Butanol Fraction on Glycogen Content and Some Energy Related Enzymes in the Cestode, Raillietina echinobothrida
The result indicates that the intrusion of the phytoconstituents in the function of enzymes of energy generating pathway of R. echinobothrida, perhaps dispossesses the parasite from energy production leading to paralysis.
Biological significance of phosphoenolpyruvate carboxykinase in a cestode parasite, Raillietina echinobothrida and effect of phytoestrogens on the enzyme from the parasite and its host, Gallus domesticus
The potential of these findings to validate PEPCK as the anthelmintic drug target for parasitism management is stressed, as antagonist behaviours of recombinantPEPCKs derived from the parasite and its host are reported.
Purification and characterization of phosphoenolpyruvate carboxykinase from Raillietina echinobothrida, a cestode parasite of the domestic fowl
It is hypothesized that PEPCK may be a potential target site for anthelmintic action after it was purified from the parasite and its avian host and tested on phytochemicals from plant sources, which resulted in alteration of its activity.
Effects of Acacia oxyphylla and Securinega virosa on functional characteristics of Raillietina echinobothrida (Phylum: Platyhelminthes; Class: Cestoidea), a poultry cestode parasite
Role of phyto-products in the changed physiology of cestode and their possible chemotherapeutic targets are discussed and a lot of disparity was noted in the free amino acid pool as the levels of many amino acids were seen to increase or decrease in relation to the levels observed in control parasites.
Effect of Punica granatum fruit peel on glucose-6-phosphate dehydrogenase and malate dehydrogenase in amphistome Gastrothylax indicus
Following in vitro treatment with ethanolic and aqueous extracts of Punica granatum fruit peel and commercial anthelmintic, albendazole G-6-PDH activity was decreased, whereas MDH was suppressed by 24–41 %, compared to the respective control, indicating that phytochemicals of plant may act as potential vermifuge or vermicide.
Differential kinetics at PK/PEPCK branch point in the cestode, Raillietina echinobothrida.
Genistein: is the multifarious botanical a natural anthelmintic too?
The potential beneficial role of genistein as a natural alternative in management of helminth parasites needs to be further explored, particularly considering its in vivo efficacy and pharmacokinetics.


Effects of mebendazole, albendazole, and praziquantel on succinate dehydrogenase, fumarate reductase, and malate dehydrogenase in Echinococcus granulosus cysts harbored in mice.
The results suggested that MD may not be an important target for the antihydatidosis drugs and that the cyst wall may utilize a partial reverse tricarboxylic acid cycle.
In vitro anthelmintic activity of root-tuber extract of Flemingia vestita, an indigenous plant in Shillong, India
In vitro treatment of root-tuber-peel extract of Flemingia vestita against helminth parasites showed structural alteration in their tegumental architecture and the vermifugal activity of this plant extract was suggested.
Effect of some anthelmintics on malate dehydrogenase activity and mortality in two avian nematodes Ascaridia galli and Heterakis gallinae.
Assay of malate dehydrogenase, following the in vitro drug treatment cambendazole and tiabendazoles, exhibited moderate inhibition of the activity in both the parasites.
Enzymes of PEP-succinate pathway in Setaria cervi and effect of anthelmintic drugs.
Localization of different enzymes of PEP-succinate pathway has been done in Setaria cervi, a bovine filarial worm and centperazine, an antifilarial drug being developed by CDRI showed significant inhibitory action on pyruvate kinase, lactate dehydrogenase, fumarase and succinate dehydrogensase.
The effect of five fasciolicides on malate dehydrogenase activity and mortality of Fasciola gigantica, Fasciolopsis buski and Paramphistomum explanatum.
The effect of oxyclozanide, hexachlorophene, nitroxynil, rafoxanide and diamphenethide on malate dehydrogenase activity of homogenates of Fasciola gigantica, Fasciolopsis buski and Paramphistomum
Effect of artemether on glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase, and pyruvate kinase of Schistosoma japonicum harbored in mice.
  • S. Xiao, J. You, Z. Feng
  • Biology, Chemistry
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
  • 1998
In the glycolytic pathway of both Male and Female schistosomes, PGK and PK activities were inhibited by Art, and the Art reduced lactate content more in Female than in Male worms.