Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action.

@article{Krcken2012AnthelminticCC,
  title={Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action.},
  author={J{\"u}rgen Kr{\"u}cken and Achim Harder and Peter Jeschke and Lindy Holden-Dye and Vincent O'Connor and Claudia Welz and Georg von Samson-Himmelstjerna},
  journal={Trends in parasitology},
  year={2012},
  volume={28 9},
  pages={385-94}
}
The broad-spectrum anthelmintic cyclooctadepsipeptide PF1022A is a fungal metabolite from Rosellinia sp. PF1022, which is a Mycelia sterilia found on the leaves of Camellia japonica. A broad range of structurally related cyclooctadepsipeptides has been characterized and tested for anthelmintic activities. These metabolites have been used as starting points to generate semisynthetic derivatives with varying nematocidal capacity. Predominant among these compounds is emodepside, which exhibits a… CONTINUE READING

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