Anterograde transport of HSV-1 and HSV-2 in the visual system

  title={Anterograde transport of HSV-1 and HSV-2 in the visual system},
  author={R. Norgren and J. H. McLean and H. Bubel and Arden H. Wander and M. Lehman},
  journal={Brain Research Bulletin},
  • R. Norgren, J. H. McLean, +2 authors M. Lehman
  • Published 1992
  • Biology, Medicine
  • Brain Research Bulletin
  • The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect… CONTINUE READING
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