Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors.

  title={Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors.},
  author={Kevin T. Beier and Arpiar B. Saunders and Ian Ant{\'o}n Oldenburg and Kazunari Miyamichi and Nazia Akhtar and Liqun Luo and Sean P J Whelan and Bernardo L. Sabatini and Constance L. Cepko},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 37},
To understand how the nervous system processes information, a map of the connections among neurons would be of great benefit. Here we describe the use of vesicular stomatitis virus (VSV) for tracing neuronal connections in vivo. We made VSV vectors that used glycoprotein (G) genes from several other viruses. The G protein from lymphocytic choriomeningitis virus endowed VSV with the ability to spread transsynaptically, specifically in an anterograde direction, whereas the rabies virus… CONTINUE READING
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