Anterograde Jelly belly and Alk Receptor Tyrosine Kinase Signaling Mediates Retinal Axon Targeting in Drosophila

  title={Anterograde Jelly belly and Alk Receptor Tyrosine Kinase Signaling Mediates Retinal Axon Targeting in Drosophila},
  author={Eleni Bazigou and Holger Apitz and Jana Johansson and Christina E. Lor{\'e}n and Elizabeth M. A. Hirst and Pei-Ling Chen and Ruth H. Palmer and Iris Salecker},

Figures from this paper

Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap
It is concluded that Jeb-Alk expression and anterograde trans-synaptic signaling are modulated by Mtg and play a key role in establishing functional synaptic connectivity in the developing motor circuit.
Jelly belly trans‐synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture
Novel roles for Jeb–Alk signaling in the modulation of synaptic function and structure have potential implications for recently reported Alk functions in human addiction, retention of spatial memory, cognitive dysfunction in neurofibromatosis, and pathogenesis of amyotrophic lateral sclerosis.
R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners
It is proposed that Loaf regulates the trafficking or function of one or more cell surface proteins, and an excess of these proteins on the synaptic partners of R7 prevents the formation of stable connections.
Assessing the Role of Cell-Surface Molecules in Central Synaptogenesis in the Drosophila Visual System
The results indicate that cell-surface molecules are able to dictate synapse loci by changing the axon terminal identity in a partially cell-autonomous manner, but that presynapse formation at specific sites also requires complex interactions between pre- and post-synaptic elements.
The Cytoplasmic LIM Domain Protein Espinas Contributes to Photoreceptor Layer Selection in the Visual System
It is proposed that Esn signals downstream of Fmi to stabilize R8 axons in their final target layer, which suggests that Fmi intracellular signaling is also relevant for R8 final layer selection.
Robo-3–mediated repulsive interactions guide R8 axons during Drosophila visual system development
The transient cell-specific expression of Roundabout-3 (Robo3), an axon-guidance receptor, is expressed specifically and transiently in R8 growth cones and plays a crucial role in establishing neural circuits in the Drosophila visual system by selectively regulating pathway choice for posterior-most R8growth cones.
Transcriptional Control of Photoreceptor Axon Growth and Targeting in Drosophila melanogaster
It is found that the transcriptional repressor Tramtrack69 (Ttk69) is required for normal accumulation of the Activin effector dSmad2 in R7 nuclei, suggesting that Ttk69 promotes Activin signaling to regulate R7 axon growth.


Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers
It is shown that the Jeb receptor is the Drosophila homologue of anaplastic lymphoma kinase (Alk), a receptor tyrosine kinase of the insulin receptor superfamily, a receptorTyrosine Kinase ofThe insulin receptorsuperfamily is shown to be a signal to organize the development of visceral muscles.
Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion
It is shown that Drosophila Alk is the receptor for Jeb in the developing visceral mesoderm, and that Jeb binding stimulates an Alk-driven, extracellular signal-regulated kinase-mediated signalling pathway, which results in the expression of the downstream gene duf—needed for muscle fusion.
The protocadherin Flamingo is required for axon target selection in the Drosophila visual system
It is proposed that Flamingo-mediated interactions between R-cell growth cones within the target field regulate target selection in Drosophila visual system.
Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics.
It is suggested that PTP69D plays a permissive role, perhaps reducing the adhesion of R1-R6 and R7 growth cones to the pioneer R8 axon so that they can respond independently to their specific targeting cues.
Morphogens and synaptogenesis in Drosophila.
Genetic analysis suggests that additional signaling molecules are required for synaptic growth at the Drosophila neuromuscular junction as well as an emerging anterograde signaling pathway.
Drosophila JAB1/CSN5 Acts in Photoreceptor Cells to Induce Glial Cells
Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system
The data presented here identify ALK as a novel candidate receptor for regulating critical events in the development of neurons in both the central and the peripheral nervous systems.
Molecular mechanisms of axon guidance.