Anterior temporal lobe degeneration produces widespread network-driven dysfunction.

  title={Anterior temporal lobe degeneration produces widespread network-driven dysfunction.},
  author={Christine Cong Guo and Maria Luisa Gorno-Tempini and Benno Gesierich and Maya L. Henry and Andrew Trujillo and Tal Shany-Ur and Jorge Jovicich and Simon Daniel Robinson and Joel H. Kramer and Katherine P. Rankin and Bruce L. Miller and William W. Seeley},
  journal={Brain : a journal of neurology},
  volume={136 Pt 10},
The neural organization of semantic memory remains much debated. A 'distributed-only' view contends that semantic knowledge is represented within spatially distant, modality-selective primary and association cortices. Observations in semantic variant primary progressive aphasia have inspired an alternative model featuring the anterior temporal lobe as an amodal hub that supports semantic knowledge by linking distributed modality-selective regions. Direct evidence has been lacking, however, to… CONTINUE READING
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