Anterior segment physiology after bumetanide inhibition of Na-K-Cl cotransport.

  title={Anterior segment physiology after bumetanide inhibition of Na-K-Cl cotransport.},
  author={B T Gabelt and Michael Wiederholt and Abbot F. Clark and Paul L. Kaufman},
  journal={Investigative ophthalmology & visual science},
  volume={38 9},
PURPOSE To determine the effect of bumetanide inhibition of Na-K-Cl cotransport on aqueous humor formation and outflow facility in living cynomolgus monkeys, outflow facility in organ-cultured human eyes, and contraction in bovine ciliary muscle and trabecular meshwork strips, in vitro. METHODS Aqueous humor formation in monkeys was measured fluorophotometrically for 6 hours, 1 to 6 weeks before, immediately after, and 2 to 6 weeks after bumetanide was administered intravitreally (final… CONTINUE READING


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